IRAK inhibitor 1
IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.
Product Specifications
CAS Number
[1042224-63-4]
UNSPSC
12352005
Hazard Statement
H301+H311, H311, H331
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/IRAK-inhibitor-1.html
Purity
99.83
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
C1(C2=CN=C3N2C=CC=C3)=CC=CC(NC4CCNCC4)=N1
Molecular Formula
C17H19N5
Molecular Weight
293.37
Precautions
H301+H311, H311, H331
References & Citations
[1]Buckley GM, et al. IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding. Bioorg Med Chem Lett. 2008 Jun 1;18 (11) :3291-5.|[2]Li S, et al. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99 (8) :5567-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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