P5 (PEG24) -VC-PAB-Exatecan

P5 (PEG24) -VC-PAB-Exatecan (LP5) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan (HY-13631) and a linker P5 (PEG24) -VC-PAB to make antibody agent conjugate (ADC) . P5 (PEG24) -VC-PAB-Exatecan can be used for the research of tumor[1].

Product Specifications

CAS Number

[2928571-43-9]

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p5-peg24-vc-pab-exatecan.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N[C@H]2CCC3=C4C2=C5C(C(N6C5)=CC([C@](CC)(O)C(OC7)=O)=C7C6=O)=NC4=CC(F)=C3C)=O)=O)=O)C8=CC=C(NP(C#C)(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O)C=C8

Molecular Formula

C100H151FN9O36P

Molecular Weight

2105.28

References & Citations

[1]Schmitt S, et al. Design and evaluation of phosphonamidate-linked exatecan constructs for highly loaded, stable, and efficacious Antibody-Drug-Conjugates. Mol Cancer Ther. 2023 Oct 12.