P5(PEG24)-VC-PAB-exatecan
Product Specifications
UNSPSC Description
P5(PEG24)-VC-PAB-exatecan is a camptothecin-based linker-payload platform based on the highly potent camptothecin derivative exatecan. P5(PEG24)-VC-PAB-exatecan has linker-payload structures. P5(PEG24)-VC-PAB-exatecan can be used for the research of tumor[1].
Target Antigen
Drug-Linker Conjugates for ADC; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p5-peg24-vc-pab-exatecan.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=P(C#C)(NC1=CC=C(C=C1)C(N[C@@H](C(C)C)C(N[C@H](C(NC2=CC=C(C=C2)COC(N[C@H]3CCC4=C5C(N=C6C7=CC8=C(C(N7CC6=C53)=O)COC([C@@]8(CC)O)=O)=CC(F)=C4C)=O)=O)CCCNC(N)=O)=O)=O)OCCOCCO.[23]
Molecular Weight
2105.31
References & Citations
[1]Schmitt S, et al. Design and evaluation of phosphonamidate-linked exatecan constructs for highly loaded, stable, and efficacious Antibody-Drug-Conjugates. Mol Cancer Ther. 2023 Oct 12.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163099/P5-PEG24-VC-PAB-exatecan-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163099/P5-PEG24-VC-PAB-exatecan-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2928571-43-9
Available Sizes
Curated Selection
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