VEGFR-2/STAT-3-IN-1

VEGFR-2/STAT-3-IN-1 (Compound 9f) is a dual inhibitor for VEGFR-2 (IC50=26.3 nM) and STAT-3 (IC50=5.63 nM) . VEGFR-2/STAT-3-IN-1 inhibits the proliferation of cancer cells PANC1 and PC3 with IC50 of 0.14 and 0.10 µM. VEGFR-2/STAT-3-IN-1 induces apoptosis in PC3[1].

Product Specifications

UNSPSC

12352005

Target

STAT; VEGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-stat-3-in-1.html

Smiles

O=C(N1C(C2=CC=CC=C2)=O)/C(C3=C1C=CC=C3)=N\NC(C4=C(C)N(C5=CC=C(OC)C=C5)N=N4)=O

Molecular Formula

C26H20N6O4

Molecular Weight

480.47

References & Citations

[1]Elsebaie HA, et al., Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments. Bioorg Chem. 2024 Jul 10;151:107626.