PROTAC SARS-CoV-2 Mpro degrader-3
Product Specifications
UNSPSC Description
PROTAC SARS-CoV-2 Mpro degrader-3 (Compound P2) exhibits antiviral activity through the degradation of the main protease (Mpro) of human coronaviruses (HCoVs) (DC50=27 μM). PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC50 of 4.6 μM, 4.6 μM, and 0.71 μM, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. (Pink: ligand for target protein Mpro ligand 2 (HY-161791); Black: linker (HY-161792); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) [1].
Target Antigen
PROTACs; SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/protac-sars-cov-2-mpro-degrader-3.html
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)COCCCCCN4N=NC(COC5=CC=C(COC(N[C@H](C(N[C@@H](C[C@@H]6CCNC6=O)C(O)S(=O)(O[Na])=O)=O)CC(C)C)=O)C=C5)=C4
Molecular Weight
1161.33
References & Citations
[1]Cheng S,et al., Development of novel antivrial agents that induce the degradation of the main protease of human-infecting coronaviruses. Eur J Med Chem. 2024 Jun 25;275:116629.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161789/PROTAC-SARS-CoV-2-Mpro-degrader-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161789/
Clinical Information
No Development Reported
Curated Selection
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