TRH-βNA

TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity[1][2].

Product Specifications

CAS Number

[73644-58-3]

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

Biochemical Assay Reagents

Type

Peptides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/trh-βna.html

Solubility

H2O

Smiles

O=C([C@H]1NC(CC1)=O)N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(NC4=CC5=C(C=CC=C5)C=C4)=O)=O

Molecular Formula

C26H28N6O4

Molecular Weight

488.54

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Müller-Fielitz H, et al. Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun. 2017 Sep 7;8 (1) :484.|[2]Alvarez-Salas E, et al. Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II. Endocrinology. 2012 Aug;153 (8) :4067-76.