EP2 receptor antagonist-2

EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA) [1].

Product Specifications

CAS Number

[615273-95-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/ep2-receptor-antagonist-2.html

Purity

98.69

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC(F)(C1=CC(C2=CC=CC=C2)=NC(N3CCOCC3)=N1)F

Molecular Formula

C15H14F3N3O

Molecular Weight

309.29

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Jiang J, et al. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9 (4) :699-707.