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BRL-15572 (dihydrochloride)

BRL-15572 dihydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1].

Product Specifications

CAS Number

193611-72-2

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brl-15572-dihydrochloride.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(CN1CCN(C2=CC(Cl)=CC=C2)CC1)C(C3=CC=CC=C3)C4=CC=CC=C4.[H]Cl.[H]Cl

Molecular Formula

C25H29Cl3N2O

Molecular Weight

479.87

References & Citations

[1]Price GW, et, al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep; 356 (3) : 312-20.|[2]Geovanna NQ, et, al. Antinociceptive effect of (-) -epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr; 29 (2 and 3-Spec Issue) : 270-279.|[3]Hagan JJ, et, al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23; 331 (2-3) : 169-74.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor; mLAG-3

Available Sizes

Frequently Asked Questions

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