TKIM
TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1[1].
Product Specifications
CAS Number
326921-25-9
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tkim.html
Purity
99.73
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NNC(CSC1=NC2=CC=CC=C2C=C1)=O)C3=CC=C(Cl)C=C3
Molecular Formula
C18H14ClN3O2S
Molecular Weight
371.84
References & Citations
[1]Yuqin Ma, et al. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating. J Med Chem. 2020 Oct 8;63 (19) :10972-10983.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
