Gallein
Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity[1][3].
Product Specifications
CAS Number
[2103-64-2]
Product Name Alternative
Pyrogallol phthalein
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Dye Reagents
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gallein.html
Purity
98.0
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1OC2(C3=C(OC4=C2C=CC(O)=C4O)C(O)=C(O)C=C3)C5=C1C=CC=C5
Molecular Formula
C20H12O7
Molecular Weight
364.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Sanz G, et al, Gallein, a Gβγ subunit signalling inhibitor, inhibits metastatic spread of tumour cells expressing OR51E2 and exposed to its odorant ligand. BMC Res Notes. 2017 Oct 30;10 (1) :541. |[2]Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. Gallein increases the fibroblast growth factor 2-elicited osteoprotegerin synthesis in osteoblasts. Biochim Biophys Acta Gen Subj. 2024 Aug;1868 (8) :130635. |[3]Alarabi AB, et al. The G-protein βγ subunits regulate platelet function. Life Sci. 2020 Dec 1;262:118481.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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