PD150606

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective[1].

Product Specifications

CAS Number

[179528-45-1]

UNSPSC

12352005

Hazard Statement

H301, H315, H317, H318, H335

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PD150606.html

Purity

98.61

Solubility

DMSO : ≥ 28 mg/mL

Smiles

O=C(O)/C(S)=C/C1=CC=C(I)C=C1

Molecular Formula

C9H7IO2S

Molecular Weight

306.12

Precautions

H301, H315, H317, H318, H335

References & Citations

[1]1. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93 (13) :6687-92.|[2]2. Squier MK , et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178 (3) :311-9.