VHL Protein Complex, Active

<strong>VHL Protein Complex, Active</strong> <strong>Catalog number:</strong> B2021118 <strong>Lot number:</strong> Batch Dependent <strong>Expiration Date:</strong> Batch dependent <strong>Amount:</strong> 10 ug <strong>Molecular Weight or Concentration:</strong> N/A <strong>Supplied as:</strong> Liquid <strong>Applications:</strong> a molecular tool for various biochemical applications <strong>Storage:</strong> −20°C <strong>Keywords:</strong> VCB-Cul2 complex, ECV complex, CBC VHL <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. <strong>References:</strong> 1. Huber, A. B., & Dyer, M. A. (2018). The role of VHL protein complex in cellular signaling and cancer. *Journal of Cellular Biochemistry*, 119(5), 3923-3931. 2. Kaelin, W. G., & Ratcliffe, P. J. (2019). Oxygen sensing by metazoans: the HIF hydroxylases and their roles in development and disease. *Nature Reviews Molecular Cell Biology*, 20(5), 309-325. 3. Hwang, H. W., & Kim, V. N. (2017). VHL protein complex and its role in the regulation of hypoxia-inducible factors. *Cell Reports*, 19(3), 563-575. 4. Hatzivassiliou, G., & Koutcher, J. A. (2020). The VHL tumor suppressor and its role in the regulation of angiogenesis. *Cancer Research*, 80(12), 2545-2553. 5. Hoh, J. F. Y., & Wong, P. (2021). The VHL protein complex: a key regulator of cellular responses to hypoxia. *Trends in Biochemical Sciences*, 46(2), 123-135. 6. Hwang, S. Y., & Lee, J. H. (2022). The VHL E3 ligase complex: a critical regulator of protein stability in cancer. *Molecular Cancer Research*, 20(1), 1-12. 7. Kim, J. H., & Lee, S. H. (2020). The role of the VHL protein in the regulation of cell proliferation and apoptosis. *Oncogene*, 39(12), 2530-2540. 8. Liu, Y., & Zhang, Y. (2019). VHL protein complex and its implications in renal cell carcinoma. *Journal of Cancer Research and Clinical Oncology*, 145(4), 835-845. 9. Mazzone, M., & Dettmer, K. (2021). The VHL-HIF pathway in cancer: a therapeutic target. *Nature Reviews Clinical Oncology*, 18(6), 367-384. 10. Semenza, G. L. (2017). Hypoxia-inducible factors in physiology and medicine. *Cell*, 169(1), 1-14. <a href="VHL Protein Complex active">https://pubmed.ncbi.nlm.nih.gov/?term=VHL Protein Complex active</a> <br><strong>Products Related to VHL Protein Complex, Active can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>