Inupadenant (hydrochloride)

Inupadenant (EOS-850) hydrochloride is an orally active, highly selective A2A receptor antagonist. Inupadenant hydrochloride can not cross BBB. Inupadenant hydrochloride can enhance the humoral immune response and has anti-tumor activity[1].

Product Specifications

CAS Number

[2411004-22-1]

Product Name Alternative

EOS-850 (hydrochloride)

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/inupadenant-hydrochloride.html

Purity

99.60

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1SC(C2=NC(C3=CC=CO3)=NN2C(N)=N4)=C4N1CCN5CCN(C(C(F)=C6)=CC(OCC[S@](C)=O)=C6F)CC5.[H]Cl

Molecular Formula

C25H27ClF2N8O4S2

Molecular Weight

641.11

References & Citations

[1]Laurence Buisseret, et al. Phase 1 trial of the adenosine A2Areceptor antagonist inupadenant (EOS-850) : Update on tolerability, and antitumor activity potentially associated with the expression of the A2A receptor within the tumor. Journal of Clinical Oncology. Volume 39, Issue 15_suppl.