Sheep anti Mouse Disabled-1 (CT)
Product Specifications
Background
Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled Ð1 acts downstream of reelin in a signalling pathway.
Synonyms
Disabled homolog 1, DAB1
UniProt
P97318 (Mouse)
Host
Sheep
Species Reactivity
Mouse
Isotype
IgG
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IP
Field of Research
Signal Transduction
Purification Method
Ammonium Sulfate Precipitation
Assay Principle
Immunoblotting at 1 µg/mL, Immunoprecipitation at 5µg/mL. Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as a 0,2um sterile filter solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1.Homayouni,R. et.al (1999) J. Neuroscience 19(17), 7505-7515 2.Rice,d.s. et.al. (1998) Development 125 ,3710-3729
Shipping Conditions
Room Temperature
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
CAS Number
9007-83-4
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