Sheep anti Mouse Disabled-1 (CT)

Product Specifications

Background

Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled Ð1 acts downstream of reelin in a signalling pathway.

CAS Number

9007-83-4

Synonyms

Disabled homolog 1, DAB1

UniProt

P97318 (Mouse)

Host

Sheep

Species Reactivity

Mouse

Isotype

IgG

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

WB, IP

Field of Research

Signal Transduction

Purification Method

Ammonium Sulfate Precipitation

Assay Principle

Immunoblotting at 1 µg/mL, Immunoprecipitation at 5µg/mL. Optimal concentration should be evaluated by serial dilutions.

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided as a 0,2um sterile filter solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.