(2R,3S) -PD-1/PD-L1-IN-38

(2R,3S) -PD-1/PD-L1-IN-38 (Compound (±) -13e) is an orally active Ah receptor (AhR) antagonist with in vivo and in vitro anticancer activity. (2R,3S) -PD-1/PD-L1-IN-38 promotes the secretion of INF-γ by CD8+T cells and inhibits the signal transduction of PD-1/PD-L1[1].

Product Specifications

UNSPSC

12352005

Target

Aryl Hydrocarbon Receptor; PD-1/PD-L1

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2r-3s-pd-1-pd-l1-in-38.html

Solubility

10 mM in DMSO

Smiles

CC(C1=CC2=C(C3=C(C(C)=C(C=C3)C)C=C2)C4=C1O[C@@H](OC(C)=O)[C@@H](C5=CC=CC=C5)O4)C

Molecular Formula

C29H28O4

Molecular Weight

440.53

References & Citations

[1]Li Z, et al. Discovery of Natural Ah Receptor Antagonists from Salvia miltiorrhiza Bunge and Synthesis of Analogs for Tumor Immunotherapy[J]. Journal of Medicinal Chemistry, 2024.