JET-209
JET-209 is a potent CBP/p300 PROTAC degrader, with DC50 values of 0.05 nM and 0.2 nM for CBP and p300. JET-209 demonstrates remarkable anti-tumor activity against various acute leukemia cell lines and effectively inhibits tumor growth in xenograft tumor models. JET-209 can be used for the study of acute leukemia (Pink: CBP/p300 ligand ; Blue: CRBN ligand (HY-132248) ; Black: Linker; CBP/p300 ligand + Linker (HY-175621) ).
Product Specifications
CAS Number
3033714-58-5
UNSPSC
12352005
Target
Histone Acetyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jet-209.html
Concentration
10mM
Purity
98.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1CCC2=C(C(C3=CC=CC4=C3C=NC(C5=CN=C(C=C5)C(NC6CCN(CC6)C7=CC8=C(C(N(C8)C9CCC(NC9=O)=O)=O)C=C7)=O)=C4)=NN2C%10CCOCC%10)C1)=O
Molecular Formula
C46H47N9O6
Molecular Weight
821.92
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; Cereblon
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
RCBTB2 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
