Cyprodinil-13C6
Product Specifications
Product Name Alternative
NVP-AEE 788
UNSPSC Description
Cyprodinil-13C6 is the 13C6 labeled Cyprodinil. Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC50=1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC50=15.1 µM).
Target Antigen
Androgen Receptor; Fungal; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Others;Vitamin D Related/Nuclear Receptor
Field of Research
Infection; Endocrinology
Assay Protocol
https://www.medchemexpress.com/cyprodinil-13c6.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(C2CC2)=NC(N[13C]3=[13CH][13CH]=[13CH][13CH]=[13C]3[H])=N1
Molecular Weight
231.24
References & Citations
[1]Frances Orton, et al. Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ Health Perspect. 2011 Jun;119(6):794-800.|[2]Masner, P., et al. Possible methionine biosynthesis inhibition by pyrimidinamine fungicides. Pestic. Sci. 42(3),163-166 (1994).|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116214S1/Cyprodinil-13C6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116214S1/
Clinical Information
No Development Reported
CAS Number
1773496-63-1
Available Sizes
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