MS182
Product Specifications
CAS Number
3034773-62-8
UNSPSC Description
MS182 (compound 11) is an acetylation targeting chimera (AceTAC) designed based on p53Y220C stabilizer and targeting p53Y220C. MS182 is composed of p53Y220C and p300/CBP binders, respectively, coupled by a linker. MS182 forms a ternary complex with p300/CBP acetyltransferase and p53Y220C in a time- and concentration-dependent manner, effectively acetylating lysine at position 382 of p53Y220C (ACE50: 1.52 μM). MS182 also exhibited considerable bioavailability in mice, with GI50 values of 2.16 μM and 1.83 μM for BxPC3 (p53Y220C/-) and NUGC (p53Y220C/+), respectively[1].
Target Antigen
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/ms182.html
Smiles
O=C(NCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1F)CCOCCOCCOCCNCC6=CC7=C(C=C6)N(CC)C8=C7C=CC(C9=CC(C)=CS9)=C8
Molecular Weight
1014.26
References & Citations
[1]Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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