KOR/DOR agonist 1
KOR/DOR agonist 2 is a KOR and DOR opioid receptors agonist with Ki values of 0.14 nM, and 0.93 nM, respectively. KOR/DOR agonist 2 shows significant antinociceptive effects. KOR/DOR agonist 2 penetrates the blood-brain barrier[1].
Product Specifications
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kor-dor-agonist-1.html
Smiles
O[C@]12[C@@]3(C4=C(C(O)=CC=C4C[C@H]2N(CC3)CC5CC5)O6)[C@@H]6[C@H](CC1)N(C(/C=C/C7=CC=CO7)=O)C
Molecular Formula
C28H32N2O5
Molecular Weight
476.56
References & Citations
[1]Celsey M St Onge, et al. Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. J Med Chem. 2024 May 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
δ Opioid Receptor/DOR; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR
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