KOR/DOR agonist 1

KOR/DOR agonist 2 is a KOR and DOR opioid receptors agonist with Ki values of 0.14 nM, and 0.93 nM, respectively. KOR/DOR agonist 2 shows significant antinociceptive effects. KOR/DOR agonist 2 penetrates the blood-brain barrier[1].

Product Specifications

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kor-dor-agonist-1.html

Smiles

O[C@]12[C@@]3(C4=C(C(O)=CC=C4C[C@H]2N(CC3)CC5CC5)O6)[C@@H]6[C@H](CC1)N(C(/C=C/C7=CC=CO7)=O)C

Molecular Formula

C28H32N2O5

Molecular Weight

476.56

References & Citations

[1]Celsey M St Onge, et al. Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. J Med Chem. 2024 May 30.