Icomidocholic acid

Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) [1][2][3].

Product Specifications

CAS Number

[246529-22-6]

Product Name Alternative

Aramchol; C20-FABAC

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Stearoyl-CoA Desaturase (SCD)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/icomidocholic-acid.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@@H](NC(CCCCCCCCCCCCCCCCCCC)=O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C

Molecular Formula

C44H79NO5

Molecular Weight

702.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Iruarrizaga-Lejarreta M, et al. Role of Aramchol in steatohepatitis and fibrosis in mice. Hepatol Commun. 2017 Nov;1 (9) :911-927.|[2]Bhattacharya D, et al. Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis. JHEP Rep. 2021 Jan 28;3 (3) :100237.|[3]Gilat T, et al. Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in inbred mice. Lipids. 2001 Oct;36 (10) :1135-40.