Tesmilifene (fumarate)

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].

Product Specifications

CAS Number

[1185241-83-1]

Product Name Alternative

DPPE (fumarate)

UNSPSC

12352005

Hazard Statement

H302, H319, H372, H410

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tesmilifene-fumarate.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.O=C(O)/C=C/C(O)=O

Molecular Formula

C23H29NO5

Molecular Weight

399.48

Precautions

H302, H319, H372, H410

References & Citations

[1]Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66 (4) :715-31.|[2]G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9.