Tesmilifene (fumarate)
Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].
Product Specifications
CAS Number
1185241-83-1
Product Name Alternative
DPPE (fumarate)
UNSPSC
12352005
Hazard Statement
H302, H319, H372, H410
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tesmilifene-fumarate.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.O=C(O)/C=C/C(O)=O
Molecular Formula
C23H29NO5
Molecular Weight
399.48
Precautions
H302, H319, H372, H410
References & Citations
[1]Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66 (4) :715-31.|[2]G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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