2'-Deoxyuridine-d2-1

2'-Deoxyuridine-d2-1 is the deuterium labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

Product Specifications

CAS Number

[40632-23-3]

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

O=C1N(C([2H])=C([2H])C(N1)=O)[C@]2([H])O[C@@H]([C@H](C2)O)CO

Molecular Formula

C9H10D2N2O5

Molecular Weight

230.21

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26 (1) :1-5.