PL-3994
PL-3994 is a natriuretic peptide receptor-A (NPR-A) agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. PL-3994 produces concentration-dependent relaxation of pre-contracted guinea-pig trachea with an IC50 value of 42.7 nM[1].
Product Specifications
CAS Number
952295-80-6
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pl-3994.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC(CNC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC2)NC(CCCCCC)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)C)=O)=O)CCCNC(N)=N)=O)CCCC)=O)CC(O)=O)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)CO)=O)=O)C(N5[C@H](C(N[C@H](C5)C(N)=O)=O)CCCNC(N)=N)=O
Molecular Formula
C82H127N27O20S2
Molecular Weight
1875.18
References & Citations
[1]Edelson JD, et al. In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo (Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys) -Tyr-[Arg mimetic]-NH (2) ) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 Apr;26 (2) :229-38. |[2]Edelson JD, et al. In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo (Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys) -Tyr-[Arg mimetic]-NH (2) ) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 Apr;26 (2) :229-38.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2
Frequently Asked Questions
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