KIF18A-IN-9

KIF18A-IN-9 (Compound 1) is a potent KIF18A inhibitor, with an IC50 value of 3.8 nM. KIF18A-IN-9 has anticancer activity, with IC50 values of less than 100 nM in OVCAR3 and MDA-MB-157 cells[1].

Product Specifications

CAS Number

[3034541-82-4]

UNSPSC

12352005

Target

Kinesin; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kif18a-in-9.html

Purity

95.03

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(NS(CCO)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=NC5=C(C=NN5CCC)C=C4

Molecular Formula

C25H32N6O4S

Molecular Weight

512.62

References & Citations

[1]Liu B, et al. Kif18a inhibitor. WO2024067465A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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