JNJ-28583113
JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia[1].
Product Specifications
CAS Number
[2765255-93-2]
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnj-28583113.html
Purity
98.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CN1N=C(C2=C1CCCCC2)C3=CC=C(C(F)(F)F)C=C3)OCC
Molecular Formula
C19H21F3N2O2
Molecular Weight
366.38
References & Citations
[1]Fourgeaud L, et al. Pharmacology of JNJ-28583113: A novel TRPM2 antagonist. Eur J Pharmacol. 2019 Jun 15;853:299-307.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPM2
Available Sizes
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UQCRFS1 (Cytochrome b-c1 Complex Subunit Rieske, Mitochondrial, Complex III Subunit 5, Cytochrome b-c1 Complex Subunit 5, Rieske Iron-sulfur Protein, RISP, Ubiquinol-cytochrome c Reductase Iron-sulfur Subunit) (MaxLight 550)
UQCRFS1 (Cytochrome b-c1 Complex Subunit Rieske, Mitochondrial, Complex III Subunit 5, Cytochrome b-c1 Complex Subunit 5, Rieske Iron-sulfur Protein, RISP, Ubiquinol-cytochrome c Reductase Iron-sulfur Subunit) (MaxLight 550)