L-Valine

L-Valine ((S) -Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase[1][2][3].

Product Specifications

CAS Number

[72-18-4]

Product Name Alternative

(S) -Valine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Akt; Arginase; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/L-Valine.html

Purity

99.89

Solubility

H2O : 20 mg/mL (ultrasonic)

Smiles

N[C@@H](C(C)C)C(O)=O

Molecular Formula

C5H11NO2

Molecular Weight

117.15

Precautions

H302, H315, H319, H335

References & Citations

[1]K Kirubavathi, et al. Synthesis, growth, structural, spectroscopic and optical studies of a new semiorganic nonlinear optical crystal: L-valine hydrochloride. Spectrochim Acta A Mol Biomol Spectrosc. 2008 Apr;69 (4) :1283-6. |[2]Zhang BH, et al., L-valine, an antialgal amino acid from Streptomyces jiujiangensis JXJ 0074 (T) . Appl Microbiol Biotechnol. 2016 May;100 (10) :4627-36.|[3]Chen XH, et al., Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens. Front Immunol. 2017 Mar 6;8:207.