SBC-115076

SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism[1][2].

Product Specifications

CAS Number

[489415-96-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/SBC-115076.html

Concentration

10mM

Purity

99.28

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1N(CCCN2CCOCC2)C(C3=CC=NC=C3)C(C(C4=CC=C(OCC5=CC=CC=C5)C(C)=C4)=O)=C1O

Molecular Formula

C31H33N3O5

Molecular Weight

527.61

Precautions

H302, H315, H319, H335

References & Citations

[1]Chanisa Thonusin, et al. The comparative effects of high dose atorvastatin and proprotein convertase subtilisin/kexin type 9 inhibitor on the mitochondria of oxidative muscle fibers in obese-insulin resistant female rats. Toxicol Appl Pharmacol. 2019 Nov 1;382:114741.|[2]Wiciński M, et al. PCSK9 signaling pathways and their potential importance in clinical practice. EPMA J. 2017;8 (4) :391-402. Published 2017 Aug 14.