(-) -Zuonin A
(-) -Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].
Product Specifications
CAS Number
84709-25-1
Product Name Alternative
D-Epigalbacin
UNSPSC
12352005
Target
JNK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-zuonin-a.html
Purity
99.99
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@H]1[C@@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)O[C@@H]1C4=CC=C(OCO5)C5=C4
Molecular Formula
C20H20O5
Molecular Weight
340.37
References & Citations
[1]Tamer S. Kaoud, et al. Manipulating JNK Signaling with (−) -zuonin A. ACS Chem Biol. 2012 Nov 16; 7 (11) : 1873–1883.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3
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