ZNL-05-044
ZNL-05-044 is a CDK11 inhibitor with an IC50s of 0.23 μM and 0.27 μM against CDK11A and CDK11B, respectively (NanoBRET assay) . ZNL-05-044 leads to G2/M cell cycle arrest and impairs RNA splicing[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/znl-05-044.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NC(N2CCN(C)CC2)=CC=C1NC3=NC(N)=C(C(C4=C(Cl)C=CC=C4Cl)=O)S3
Molecular Formula
C21H22Cl2N6OS
Molecular Weight
477.41
References & Citations
[1]Li Z, et al. Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold. Eur J Med Chem. 2022 Aug 5;238:114433.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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