Py-MAA-Val-Cit-PAB-MMAE

Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors[1][2][3].

Product Specifications

CAS Number

[2247398-68-9]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/py-maa-val-cit-pab-mmae.html

Purity

98.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CSCCC(N4CN(CN(C4)C(C=C)=O)C(C=C)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O

Molecular Formula

C72H111N13O16S

Molecular Weight

1446.79

References & Citations

[1]Zheng Dexia, et al. Anti-tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAILR2) antibody-drug conjugate (ADC) and its pharmaceutical application in antineoplastic therapy: China, CN108452320. 2018-08-28. |[2]Fang, et al. Anti-c-Met antibody drug conjugates and their applications. TWI817190B. 2023.10.01|[3]Fang, et al. Anti-mesothelin antibody and antibody-drug conjugate thereof. WO2019223579A1. 2019-11-28.