Demethylsuberosin

Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type CaV1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells[1][2][3].

Product Specifications

CAS Number

[21422-04-8]

Product Name Alternative

7-Demethylsuberosin

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Calcium Channel; NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/demethylsuberosin.html

Purity

99.71

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=CC(C/C=C(C)\C)=C(O)C=C2O1

Molecular Formula

C14H14O3

Molecular Weight

230.26

Precautions

H315, H319, H335

References & Citations

[1]Yongfen Ma, et al. Anti-inflammatory Activities of Coumarins Isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 Cells. J Food Sci Nutr Vol 14, p 179～187 (2009) .|[2]Yang X, et al. Angelica decursiva exerts antihypertensive activity by inhibiting L-type calcium channel. J Ethnopharmacol. 2023 Sep 15;313:116527.|[3]Kang SY, et al. Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Arch Pharm Res. 2007 Nov;30 (11) :1368-73.