(S) - (+) -N-3-Benzylnirvanol

(S) - (+) -N-3-Benzylnirvanol ((+) -N-3-Benzylnirvanol) is a selective and competitive cytochrome P450 (CYP) isoform CYP2C19 inhibitor with a Ki of 250 nM. (S) - (+) -N-3-Benzylnirvanol has low activity against CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, and CYP3A4[1].

Product Specifications

CAS Number

[790676-40-3]

Product Name Alternative

(+) -N-3-Benzylnirvanol

UNSPSC

12352005

Hazard Statement

H302, H319, H372, H400

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/s-plus-n-3-benzylnirvanol.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC[C@]1(C2=CC=CC=C2)C(N(C(N1)=O)CC3=CC=CC=C3)=O

Molecular Formula

C18H18N2O2

Molecular Weight

294.35

Precautions

H302, H319, H372, H400

References & Citations

[1]Suzuki H, et al. (+) -N-3-Benzyl-nirvanol and (-) -N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19. Drug Metab Dispos. 2002 Mar;30 (3) :235-9.