Phosphatidylglycerols (egg) (sodium salt)

Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV) -mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) [1][2][3].

Product Specifications

CAS Number

[383907-64-0]

Product Name Alternative

Egg PG

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/phosphatidylglycerols-egg-sodium-salt.html

Purity

99.92

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCCCCCCCCCCC(OC[C@](CC(CCCCCCC/C=C\CCCCCCCC)=O)(C)COP(OCC(O)CO)(O[Na])=O)=O

Molecular Formula

C42H80NaO9P

Molecular Weight

783.04

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen WW, et al. Phosphatidylglycerol Incorporates into Cardiolipin to Improve Mitochondrial Activity and Inhibits Inflammation. Sci Rep. 2018 Mar 20;8 (1) :4919.|[2]Numata M, et al. Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection. Proc Natl Acad Sci U S A. 2010 Jan 5;107 (1) :320-5.|[3]Poelma DL, et al. Influence of phosphatidylglycerol on the uptake of liposomes by alveolar cells and on lung function. J Appl Physiol (1985) . 2005 May;98 (5) :1784-91.