Glutamic acid (sodium salt)

Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[32221-81-1]

Product Name Alternative

Monosodium glutamate

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; HSP; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glutamic-acid-sodium-salt.html

Purity

99.23

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C(CCC(C(O)=O)N)O[Na]

Molecular Formula

C5H8NNaO4

Molecular Weight

169.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Park E, et al. Protective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death. Food Chem Toxicol. 2014 May;67:1-9.|[2]Rycerz K, et al. Effects of monosodium glutamate treatment on calretinin-immunoreactive neurons in hippocampus of postnatal rats. Folia Histochem Cytobiol. 2014;52 (4) :281-8. |[3]Ortiz GG, et al. Monosodium glutamate-induced damage in liver and kidney: a morphological and biochemical approach. Biomed Pharmacother. 2006 Feb;60 (2) :86-91. |[4]Abu-Taweel GM, et al. Cognitive and biochemical effects of monosodium glutamate and aspartame, administered individually and in combination in male albino mice. Neurotoxicol Teratol. 2014 Mar-Apr;42:60-7.|[5]Umukoro S, et al. Effect of monosodium glutamate on behavioral phenotypes, biomarkers of oxidative stress in brain tissues and liver enzymes in mice[J]. World Journal of neuroscience, 2015, 5 (5) : 339-349. |[6]Zanfirescu A, et al. Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice. Nutrients. 2017 Dec 21;10 (1) :1|[7]Zhang N , et al. Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate. Acta Pharmacol Sin. 2010 Jan;31 (1) :35-42.|[8]Yoneda J, et al. Effects of oral monosodium glutamate in mouse models of asthma. Food Chem Toxicol. 2011 Jan;49 (1) :299-304.