Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM) . Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].

Product Specifications

CAS Number

[871307-18-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

MAP3K; MAPKAPK2 (MK2) ; p38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tpl2-kinase-inhibitor-1.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=C(NC2=CC=C(F)C(Cl)=C2)C3=CC(NCC4=CC=CN=C4)=NC=C3N=C1

Molecular Formula

C21H14ClFN6

Molecular Weight

404.83

Precautions

H315, H319

References & Citations

[1]Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59 (16) :7544-60.|[2]Gavrin LK, et al. Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15 (23) :5288-92.