Voclosporin

Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor[1].

Product Specifications

CAS Number

[515814-01-4]

Product Name Alternative

ISAtx-247

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Molecular Glues; Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Voclosporin.html

Purity

99.85

Solubility

DMSO : ≥ 50 mg/mL

Smiles

C=C/C=C/C[C@@H](C)[C@H]([C@]1([H])N(C([C@](N(C([C@@H](N(C([C@](N(C([C@H](NC([C@@H](NC([C@H](CC(C)C)N(C)C([C@@](C(C)C)([H])NC([C@H](CC(C)C)N(C)C(CN(C)C([C@H](CC)NC1=O)=O)=O)=O)=O)=O)C)=O)C)=O)C)([H])CC(C)C)=O)C)CC(C)C)=O)C)([H])C(C)C)=O)C)O

Molecular Formula

C63H111N11O12

Molecular Weight

1214.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Abel MD, et al. ISATX247: a novel calcineurin inhibitor. J Heart Lung Transplant. 2001 Feb;20 (2) :161.|[2]Stalder M, et al. In vivo evaluation of the novel calcineurin inhibitor ISATX247 in non-human primates. J Heart Lung Transplant. 2003 Dec;22 (12) :1343-52.