Voclosporin
Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor[1].
Product Specifications
CAS Number
515814-01-4
Product Name Alternative
ISAtx-247
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Molecular Glues; Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Voclosporin.html
Purity
99.85
Solubility
DMSO : ≥ 50 mg/mL
Smiles
C=C/C=C/C[C@@H](C)[C@H]([C@]1([H])N(C([C@](N(C([C@@H](N(C([C@](N(C([C@H](NC([C@@H](NC([C@H](CC(C)C)N(C)C([C@@](C(C)C)([H])NC([C@H](CC(C)C)N(C)C(CN(C)C([C@H](CC)NC1=O)=O)=O)=O)=O)=O)C)=O)C)=O)C)([H])CC(C)C)=O)C)CC(C)C)=O)C)([H])C(C)C)=O)C)O
Molecular Formula
C63H111N11O12
Molecular Weight
1214.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Abel MD, et al. ISATX247: a novel calcineurin inhibitor. J Heart Lung Transplant. 2001 Feb;20 (2) :161.|[2]Stalder M, et al. In vivo evaluation of the novel calcineurin inhibitor ISATX247 in non-human primates. J Heart Lung Transplant. 2003 Dec;22 (12) :1343-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
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