Olorofim

Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318) . Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp.[1].

Product Specifications

CAS Number

[1928707-56-5]

Product Name Alternative

F901318

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Dihydroorotate Dehydrogenase; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/olorofim.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(N2CCN(C3=NC=C(F)C=N3)CC2)C=C1)C(C4=C(C5=CC=CC=C5)C=C(C)N4C)=O

Molecular Formula

C28H27FN6O2

Molecular Weight

498.55

Precautions

H315, H319, H335

References & Citations

[1]Lackner M, et al. Dihydroorotate dehydrogenase inhibitor olorofim exhibits promising activity against all clinically relevant species within Aspergillus section Terrei. J Antimicrob Chemother. 2018 Nov 1;73 (11) :3068-3073.|[2]du Pré S, et al., Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus. Antimicrob Agents Chemother. 2018 Jul 27;62 (8) :e00231-18.|[3]Seyedmousavi S, et al., Efficacy of Olorofim (F901318) against Aspergillus fumigatus, A. nidulans, and A. tanneri in Murine Models of Profound Neutropenia and Chronic Granulomatous Disease. Antimicrob Agents Chemother. 2019 May 24;63 (6) :e00129-19.