S-Nitroso-N-acetyl-DL-penicillamine

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation[1][2][3][4].

Product Specifications

CAS Number

[67776-06-1]

Product Name Alternative

SNAP

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/s-nitroso-n-acetyl-dl-penicillamine.html

Purity

98.84

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 11.11 mg/mL (ultrasonic)

Smiles

O=NSC(C)(C(C(O)=O)NC(C)=O)C

Molecular Formula

C7H12N2O4S

Molecular Weight

220.25

Precautions

H315, H319, H335

References & Citations

[1]E. Salas, et al. Comparative pharmacology of analogues of S-nitroso-N-acetyl-DL-penicillamine on human platelets. Br J Pharmacol. 1994 Aug;112 (4) :1071-6.|[2]Ioannidis I, et al. Enhanced release of nitric oxide causes increased cytotoxicity of S-nitroso-N-acetyl-DL-penicillamine and sodium nitroprusside under hypoxic conditions. Biochem J. 1996 Sep 15;318 (Pt 3) :789-95.|[3]Pravdic D, et al. Effect of nitric oxide donors S-nitroso-N-acetyl-DL-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes. Clin Exp Pharmacol Physiol. 2012 Sep;39 (9) :772-8.|[4]Mang CF, et al. Modulation of acetylcholine release in the guinea-pig trachea by the nitric oxide donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP) . Br J Pharmacol. 2000 Sep;131 (1) :94-8.