S18-000003
Product Specifications
Product Name Alternative
Stibogluconate (trisodium nonahydrate)
UNSPSC Description
S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 50>10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations[1][2].
Target Antigen
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s18-000003.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(NC(C(C)(C)C2=CC=C(NC(CC3=CC=C(S(CC)(=O)=O)C=C3)=O)C=C2F)=O)C=CC(F)=C1
Molecular Weight
518.55
References & Citations
[1]Sasaki Y, et, al. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553.|[2]Imura C, et, al. A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations. J Dermatol Sci. 2019 Mar;93(3):176-185.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119366/S18-000003-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119366/S18-000003-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2068119-11-7
Available Sizes
Curated Selection
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