Antiproliferative agent-51
Antiproliferative agent-51 (Compound 18h) exhibits inhibitory efficacy against estrogen receptor α (ERα) mediated transcription, with an IC50 of 1.6 nM. Antiproliferative agent-51 inhibits the proliferation of cancer cell ZR-75, with an IC50 of 0.031 μM. Antiproliferative agent-51 exhibits antitumor efficacy in mouse models[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-51.html
Smiles
O=C(C1=CC(OCCO)=C(C=C1)[N+]([O-])=O)NC2=CC=C(C=C2OCC(C)C)C(NC3=CC=C(C=C3OCC(C)C)C(N[C@@H]4CC[C@H](CC4)C5=CC=CC=C5)=O)=O
Molecular Formula
C43H50N4O9
Molecular Weight
766.88
References & Citations
[1]Lee T K, et al. Structure–Activity Relationship Study of Tris-Benzamides as Estrogen Receptor Coregulator Binding Modulators[J]. ACS Pharmacology & Translational Science, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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