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ADH-1

ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.

Product Specifications

CAS Number

[229971-81-7]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Cadherin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Exherin.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC1=CN=CN1)N2)=O)=O)=O)CSSC[C@H](NC(C)=O)C2=O)N

Molecular Formula

C22H34N8O6S2

Molecular Weight

570.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Shintani Y, et al. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer. 2008 Jan 1;122 (1) :71-7.|[2]Li H, et al. ADH1, an N-cadherin inhibitor, evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer. Anticancer Drugs. 2007 Jun;18 (5) :563-8.|[3]Turley RS, et al. Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg. 2015 Feb;261 (2) :368-77

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

Phase 2

Citation 01

Biochem Biophys Res Commun. 2019 Oct 5. pii: S0006-291X (19) 31851-0. |bioRxiv. 2023 Jul 25:2023.07.22.550169.|bioRxiv. 2025 Oct 24.|Cell Death Dis. 2022 Jun 20;13 (6) :557.|iScience. 2024 Feb 6;27 (3) :109119.|J Cell Mol Med. 2022 Apr;26 (8) :2392-2403.|J Pain Res. 2020 Aug 12;13:2065-2072. |Oncogene. 2022 Nov;41 (46) :5020-5031.|Sci Rep. 2019 Feb 6;9 (1) :1517.|bioRxiv. 2025 Oct 3.

Available Sizes

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