ADH-1
ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.
Product Specifications
CAS Number
229971-81-7
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Cadherin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Exherin.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC1=CN=CN1)N2)=O)=O)=O)CSSC[C@H](NC(C)=O)C2=O)N
Molecular Formula
C22H34N8O6S2
Molecular Weight
570.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Shintani Y, et al. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer. 2008 Jan 1;122 (1) :71-7.|[2]Li H, et al. ADH1, an N-cadherin inhibitor, evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer. Anticancer Drugs. 2007 Jun;18 (5) :563-8.|[3]Turley RS, et al. Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg. 2015 Feb;261 (2) :368-77
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 2
Citation 01
Biochem Biophys Res Commun. 2019 Oct 5. pii: S0006-291X (19) 31851-0. |bioRxiv. 2023 Jul 25:2023.07.22.550169.|bioRxiv. 2025 Oct 24.|Cell Death Dis. 2022 Jun 20;13 (6) :557.|iScience. 2024 Feb 6;27 (3) :109119.|J Cell Mol Med. 2022 Apr;26 (8) :2392-2403.|J Pain Res. 2020 Aug 12;13:2065-2072. |Oncogene. 2022 Nov;41 (46) :5020-5031.|Sci Rep. 2019 Feb 6;9 (1) :1517.|bioRxiv. 2025 Oct 3.
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