Metopimazine-d6
Metopimazine-d6 (EXP999-d6; RP9965-d6) is the deuterium labeled Metopimazine. Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks[1][2][3][4].
Product Specifications
CAS Number
1215315-86-8
Product Name Alternative
EXP999-d6; RP9965-d6
UNSPSC
12352005
Target
Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
C(C(C(N1CCC(C(N)=O)CC1)([2H])[2H])([2H])[2H])(N2C=3C(SC=4C2=CC=CC4)=CC=C(S(C)(=O)=O)C3)([2H])[2H]
Molecular Formula
C22H21D6N3O3S2
Molecular Weight
451.64
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
D2 Receptor
Available Sizes
Frequently Asked Questions
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