Yangonin
Product Specifications
UNSPSC Description
Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.
Target Antigen
Autophagy; Cannabinoid Receptor; NF-κB
Type
Natural Products
Related Pathways
Autophagy;GPCR/G Protein;Neuronal Signaling;NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Yangonin.html
Purity
99.79
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C=C(OC)C=C(/C=C/C2=CC=C(OC)C=C2)O1
Molecular Weight
258.27
References & Citations
[1]Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB<sub>1</sub> receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.|[2]Ma J, et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54.|[3]Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0919/Yangonin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0919/Yangonin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
500-62-9
Available Sizes
Curated Selection
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