Polygalacin D3

Polygalacin D3 is a triterpenoid saponin compound that can be extracted from the roots of the balloon flower. Polygalacin D3 can inhibit the proliferation of non-small cell lung cancer (NSCLC) cell lines by blocking the PI3K/Akt pathway, and it induces cell cycle arrest and cell apoptosis[1].

Product Specifications

CAS Number

[849758-44-7]

UNSPSC

12352005

Target

Akt; Apoptosis; PI3K

Type

Natural Products

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/polygalacin-d3.html

Smiles

O[C@H]([C@@H]([C@H]([C@@H](O1)C)O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O[C@H]3[C@@H]([C@](O)(CO3)CO)O)O)O)[C@@H]1O[C@H]([C@H]([C@H](CO4)O)O)[C@@H]4OC([C@]56[C@](CC(C)(CC6)C)([H])C7=CC[C@@]([C@@]8([C@@]([C@@](C)([C@H]([C@H](C8)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)CO)([H])CC%11)C)([H])[C@]%11(C)[C@@]7(C[C@H]5O)C)=O

Molecular Formula

C63H102O32

Molecular Weight

1371.46

References & Citations

[1]Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr;39 (4) :1702-1710.