Polygalacin D3
Polygalacin D3 is a triterpenoid saponin compound that can be extracted from the roots of the balloon flower. Polygalacin D3 can inhibit the proliferation of non-small cell lung cancer (NSCLC) cell lines by blocking the PI3K/Akt pathway, and it induces cell cycle arrest and cell apoptosis[1].
Product Specifications
CAS Number
849758-44-7
UNSPSC
12352005
Target
Akt; Apoptosis; PI3K
Type
Natural Products
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/polygalacin-d3.html
Smiles
O[C@H]([C@@H]([C@H]([C@@H](O1)C)O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O[C@H]3[C@@H]([C@](O)(CO3)CO)O)O)O)[C@@H]1O[C@H]([C@H]([C@H](CO4)O)O)[C@@H]4OC([C@]56[C@](CC(C)(CC6)C)([H])C7=CC[C@@]([C@@]8([C@@]([C@@](C)([C@H]([C@H](C8)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)CO)([H])CC%11)C)([H])[C@]%11(C)[C@@]7(C[C@H]5O)C)=O
Molecular Formula
C63H102O32
Molecular Weight
1371.46
References & Citations
[1]Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr;39 (4) :1702-1710.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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