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Tozadenant

Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.

Product Specifications

CAS Number

870070-55-6

Product Name Alternative

SYN115

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tozadenant.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC2=C(C=CC(N3CCOCC3)=C2S1)OC)N4CCC(O)(CC4)C

Molecular Formula

C19H26N4O4S

Molecular Weight

406.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Olivier Barret, et al. Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys. J Nucl Med. 2014 Oct;55 (10) :1712-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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