I-BET151
I-BET151 (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively[1][2].
Product Specifications
CAS Number
1300031-49-5
Product Name Alternative
GSK1210151A
UNSPSC
12352005
Hazard Statement
H301
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/I-BET151.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[C@@H](N1C(C(C=C(OC)C(C2=C(C)ON=C2C)=C3)=C3N=C4)=C4NC1=O)C5=CC=CC=N5
Molecular Formula
C23H21N5O3
Molecular Weight
415.44
Precautions
H301
References & Citations
[1]Seal J, et al. Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A) . Bioorg Med Chem Lett. 2012 Apr 15;22 (8) :2968-72.|[2]Chaidos A, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123 (5) :697-705.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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