PF-998425

PF-998425 is a potent, selective nonsteroidal androgen receptor (AR) antagonist with an IC50 of 37 nM and 43 nM in AR binding and cellular assays, respectively. PF-998425 has low activity on common receptors and enzymes, such as progesterone receptor. PF-998425 can be used for sebum control and androgenetic alopecia research[1].

Product Specifications

CAS Number

[1076225-27-8]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/pf-998425.html

Purity

98.31

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](CCCC1)C2=CC(C(F)(F)F)=C(C=C2)C#N

Molecular Formula

C14H14F3NO

Molecular Weight

269.26

Precautions

H302, H319

References & Citations

[1]Jie Jack Li, et al. Rational design and synthesis of 4- ((1R,2R) -2-hydroxycyclohexyl) -2 (trifluoromethyl) benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008 Nov 13;51 (21) :7010-4.